Bone Microarchitecture in Renal Osteodystrophy Patients

Aims Renal Osteodystrophy (ROD) is a systemic disorder that develops early with loss of kidney functions and is manifested by abnormalities in bone metabolism, mineralization and volume. Phosphate binders are a major constituent in chronic kidney disease management. Previous Aluminum and calcium containing phosphate binders were thought to be of detrimental effect on bone histology. The aim of this study was to investigate whether Micro-CT imaging can spot the deterioration in bone morphology (if it exists) with the use of calcium based phosphate binders. It was also our aim to evaluate the effect of the recently introduced non-calcium based phosphate binders on bone microarchitecture using quantitative Micro-CT scanning. Comparison and correlation between Micro-CT and quantitative histomorphometry for this type of bone disorder was also to be investigated.